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KMID : 0380020180330030183
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Korean Journal of Biotechnology and Bioengineering
2018 Volume.33 No. 3 p.183 ~ p.191
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Inhibitory Effect of Globefish Homogenate on the Growth of Human Colorectal Cancer Cell Lines
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Kim Jung-Hoon
Kim Jung-Hoon
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Abstract
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Cancer is one of the most serious public health problems in Korea and worldwide, and has a major impact on society. Despite significant advances in traditional anti-cancer therapies, such as chemotherapy, radiotherapy, and surgery, it remains extremely difficult to cure and prevent cancer. Consequently, novel anti-cancer therapies must be developed. We previously reported that Globefish homogenate suppresses the growth of Caco-2 human colorectal cancer cells. To build upon this previous observation, we investigated the cytotoxic effects of Globefish homogenate on DLD-1, HCT116, and SW480 human colorectal cancer cells by counting cells and examining morphological changes underneath an inverted microscope. Treatment with Globefish homogenate markedly inhibited the growth of cultured DLD-1, HCT116, and SW 480 cells in a dose-dependent manner. The sensitivities of these cells to Globefish homogenate were determined by calculating the lethal concentrations. The 50% inhibitory concentrations of Globefish homogenate were 111, 95, and 121 μg/mL in DLD-1, HCT116, and SW480 cells, respectively. These results indicate that Globefish homogenate contains a bioactive material(s) that inhibits the growth of human colorectal cancer cells.
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KEYWORD
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colorectal cancer, globefish homogenate, growth inhibition, DLD-1, HCT116, SW480
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